Endocrine Abstracts

Objective: Both overweight and obesity have been identified as risk factors for sexual dysfunction in men, but the relationship between female sexual function and amount of body fat is still obscure. To the best of our knowledge there are few reported studies assessing the relation between female sexual function index (FSFI) and body weight in women. Therefore, the aims of this study were to identify the frequency of sexual dysfunction (FSD) among obese women.<p class="abs...

Introduction: Primary hyperparathyroidism (PHPT) commonly goes unrecognized due to the physiological changes of pregnancy.PHPT is associated with significant maternal and fetal morbidity and mortality. Current evidence supports parathyroidectomy is the main treatment, performed preferably during the second trimester, when the serum calcium is above 11–mg/dl. We report the clinical course of a woman with newly diagnosed gestational PHPT who refused minimally invasive parat...

Objective: Insulin like growth factors (IGFs) are important regulators of pancreatic β cell devolopment, growth and maintanence. Mutations in the IGF genes have been found to be associated with type 2 diabetes, myocardial infarction, birth weight and obesity. These associations could result from changes in insulin secretion. We aimed to investigate IGF- 1 gene polymorphism in obese patients with insulin resistance.Methods: We included 100 obese pati...

Introduction: Megestrol acetate (MA) has been used in various cancers as a palliative agent to treat cancer cachexia. It has glucocorticoid activity and can induce significant secondary adrenal suppression. We designed this study to determine the extent of adrenal insufficiency in cancer patients receiving MA and find out whether ther was any predictive factor for this.Methods: Thirty-one patients (11 females and 20 males, aged 48–83 years) who were...

Introduction: A diagnosis of subacute thyroiditis (SAT) is readily suspected when patients present with a particular set of typical clinical and laboratory characteristics. We present a patient with atypical SAT who had no neck pain but presented with fever, and weight loss; had thyrotoxicosis with normal 99mTc uptake, and needed higher doses of steroids to resolve.Case report: A 57-year-old man presented with a fever (39  °C) of 2 month-durati...

Introduction: Resistance to thyroid hormone (RTH) is an inherited syndrome characterized by reduced responsiveness of target tissues to thyroid hormone (TH). It is characterized by high serum concentrations of free T4 (Ft4) and usually free T3 (Ft3) accompanied by normal or slightly high serum TSH concentrations. When RTH is suspected, the diagnosis should be confirmed by direct sequencing of the TR-β gene to identify mutations....

Introduction: Generously supported by IPSEN)-->Pregnancy is rare in patients with Cushing’s syndrome (CS) because of hypercortisolemia, hyperandrogenemia, and/or hyperprolactinemia. Diagnostic tests for CS have become less reliable due to the physiological changes in the hypothalamo-pituitary adrenal (HPA) axis during gestation. Some of these changes may persist until the 5th postpartum week. We report a case of Cushing...

Background: Hashimoto’s thyroiditis (HT) is a common autoimmune disease of thyroiditis. There is a relation with Vitamin D levels, vitamin D receptor (VDR) and HT reported. More than 30 gene polymorphisms are found in VDR gene. The most common four types of polymorphisms studied in autoimmune disease are FokI (exon 2), BsmI (intron 8), ApaI (intron 8) and TaqI (exon 9). The aim of this study is to investigate the association between VDR TaqI gene polymorphism and HT subty...

Background: Hashimoto’s thyroiditis is the most common autoimmune endocrine disorders and often leads to hypothyroidism. There is a relation with Vitamin D levels, vitamin D receptor (VDR) and HT reported. More than 30 gene polymorphisms are found in VDR gene. The most common four types of polymorphisms studied in autoimmune disease are FokI (exon 2), BsmI (intron 8), ApaI (intron 8) and TaqI (exon 9). The aim of this study is to investigate the association between VDR Fo...

Background: Hashimoto’s thyroiditis (HT) is one of the most common autoimmune thyroiditis that characterised by lymphocytic infiltration and thyroid hormonal disturbances. Genetic and environmental factors play a role in etiology of the disease, but genetic factors are most common. In this study, we investigated the association between Hashimoto’s thyroiditis and IL-2, IL-4, IL-5, TNF-α and IFN-γ levels.Methods: We performed a case&#1...